Determination of acid neutralising power of a commercial antacid tablet: Back Titration

Gut. Clinical data indicate that esophageal healing is influenced by both the degree and duration of gastric acid suppression.19, 20 Healing rates increase in relation to the length of time that the intragastric pH remains above 4.19 The agents used in stage III treatment of GERD include scheduled H 2 -receptor blockers, prokinetic agents and proton pump inhibitors.

Occasional indigestion caused by overeating or stress can be safely and temporarily treated with over-the-counter remedies. However, symptoms of indigestion or heartburn (a burning sensation in the chest caused by stomach acid leaking into the esophagus) can indicate more serious problems. Repeated bouts of indigestion, particularly when accompanied by severe pain or vomiting, require medical attention rather than self-medication. In addition, the label on the antacid container should be read in order to identify the active ingredient(s) and to follow the dosage recommendations carefully. Using any antacid in excessive amounts may cause acid rebound, which occurs when the stomach produces more acid than was present initially to overcome the neutralizing effects of antacids.

Objectives of the Data Analysis

Depending on the levels of hydrogen ions in the solution, the indicator pigment undergoes a chemical reaction that changes its chemical structure, making it reflect a different wavelength of light and thereby change color. To tell if something is an acid or a base, you can use a chemical called an indicator. An indicator changes color when it encounters an acid or base. There are many different types of indicators, some that are liquids and others that are concentrated on little strips of “litmus” paper. Indicators can be extracted from many different sources, including the pigment of many plants.

Lemon water

Student answers may vary. The most cost-effective antacid neutralizes the largest volume of acid for the lowest price.

Manufacturers may change antacid formulations without notice. The sample data were obtained on one set of popular antacids. Student data will vary. Please consult your current Flinn Scientific Catalog/Reference Manual for general guidelines and specific procedures, and review all federal, state and local regulations that may apply, before proceeding.

They are commonly used in conditions where it is helpful to neutralise the acid made in the stomach. For example, for acid reflux which causes heartburn.

Along with diet and lifestyle changes, they can help relieve the symptoms of occasional heartburn. Return any remaining acid from the Beral-type pipet to the graduated cylinder. Read the exact ending volume of 0.5 M HCl in the cylinder and record this value in Data Table 2. Obtain an antacid tablet from your instructor.

When the mixture turns red, have students swirl the flask and wait for no longer than one minute. If the red color remains, assume the titration is complete. Don’t worry if the color returns to yellow after 5 minutes; usually the maximum amount of acid that can still be neutralized is no more than 0.5 mL. No buffering occurs with MOM. Tums and generic antacid form buffers during their reaction with HCl.

The sample is titrated with 1.0N HCl at such a rate as to maintain a constant pH of 3.0, while recording on a strip chart the volume of acid used versus time. The titration is continued until no more acid is consumed. The times, in minutes, when 50% (T 50 ) and 90% (T 90 ) of the total antacid are consumed by the acid are determined.

There are no satisfactory clinical trials, but these preparations have little neutralizing power and are probably of little benefit in those reflux patients who have complicating esophagitis. Aluminum may protect the stomach lining from the damaging effects of alcohol and other irritants. Aluminum hydroxide inactivates the gastric digestive enzyme pepsin.

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