Pulmonary haemodynamics at rest and during exercise in patients with significant pulmonary vein stenosis after radiofrequency catheter ablation for drug resistant atrial fibrillation

Functional characterization, evolution, and influence of the ablation strategy. Arentz T, Jander N, von Rosenthal J, Blum T, Fürmaier R, Görnandt L, Neumann FJ, Kalusche D. Incidence of pulmonary vein stenosis 2 years after radiofrequency catheter ablation of refractory atrial fibrillation. Yu WC, Hsu TL, Tai CT, Tsai CF, Hsieh MH, Lin WS, Lin YK, Tsao HM, Ding YA, Chang MS, Chen SA. Acquired pulmonary vein stenosis after radiofrequency catheter ablation of paroxysmal atrial fibrillation. Robbins IM, Colvin EV, Doyle TP, Kemp WE, Loyd JE, McMahon WS, Kay GN. Pulmonary vein stenosis after catheter ablation of atrial fibrillation. Pappone C, Oreto G, Rosanio S, Vicedomini G, Tocchi M, Gugliotta F, Salvati A, Dicandia C, Calabrò MP, Mazzone P, Ficarra E, Di Gioia C, Gulletta S, Nardi S, Santinelli V, Benuzzi S, Alfieri O. Atrial remodelling after circumferential radiofrequency pulmonary vein ablation.

The published annotation (www.arabidopsis.org) was corrected as indicated below. Identical amino acids are highlighted by black, similar ones by gray shading. Genomic sequence changes in mutant alleles (designations indicated above the sequences) are shown as amino acid replacements, asterisks (stop codons) or open triangles (splice sites affected). (a) POR/HsTFC C/HsXRP2.

the PILZ group and KIS genes represent five of the six Arabidopsis orthologs of mammalian proteins involved in tubulin folding. The deduced amino acid sequence of the PFI protein is only 25% identical to that of human TFC E but shares the N-terminal CAP-Gly (formerly called CLIP170) domain involved in tubulin binding and a central region of nine loosely conserved leucine-rich repeat (LRR) motifs (Fig. ​(Fig.5c;5c; Kobe and Deisenhofer 1995; Scheel et al. 1999). The X-ray-induced allele pfi-ML375 is associated with a 10-Mb inversion that disrupts the ORF, and two other alleles have early stop-codon mutations truncating the protein at amino acid residues 14 and 40, respectively (Fig. ​(Fig.55c).

The leucine-rich repeat is a recently characterized structural motif used in molecular recognition processes as diverse as signal transduction, cell adhesion, cell development, DNA repair and RNA processing. We present here the crystal structure at 2.5 A resolution of the complex between ribonuclease A and ribonuclease inhibitor, a protein built entirely of leucine-rich repeats.

Dill T, Neumann T, Ekinci O, Breidenbach C, John A, Erdogan A, Bachmann G, Hamm CW, Pitschner HF. Pulmonary vein diameter reduction after radiofrequency catheter ablation for paroxysmal atrial fibrillation evaluated by contrast enhanced three-dimensional magnetic resonance imaging. Pappone C, Rosanio S, Oreto G, Tocchi M, Gugliotta F, Vicedomoni G, Salvati A, Dicandia C, Mazzone P, Santinelli V, Gulletta S, Chierchia S. Circumferential radiofrequency ablation of pulmonary vein ostia. A new anatomic approach for curing atrial fibrillation. Arentz T, von Rosenthal J, Blum T, Stockinger J, Bürkle G, Weber R, Jander N, Neumann FJ, Kalusche D. Feasibility and safety of pulmonary vein isolation using a new mapping and navigation system in patients with refractory atrial fibrillation.

Efficacy of an anatomic approach in a large cohort of patients with atrial fibrillation. Figure 5 Pulmonary resistance at rest, at 50 W, and at the mean maximum exercise level of 100±37 W.

Biophysicists construct complex hybrid structures using DNA and proteins

Sequence comparisons between Arabidopsis and human orthologs of tubulin-folding cofactors. The deduced amino acid sequences of the Arabidopsis proteins are based on comparisons between genomic and cDNA sequences.

The aim of our study was to reveal possible long-term complications and pulmonary haemodynamics in patients with known significant PV stenosis/occlusion after PV-RF ablation. Clinical evaluation, magnetic resonance imaging (MRI), and Swan Ganz (SG) right heart catheterization at rest and during exercise were performed. To our knowledge, we report for the first time long-term follow-up data in patients with significant PV stenosis but no or only few clinical symptoms. Our study describes morphologic changes of PV stenosis revealed by MRI and haemodynamic evaluation of pulmonary circulation at rest and during exercise.

Ler/Ws, ecotype-specific deletion of five amino acid residues (SKLPE; overlined); six helices predicted by MacVector program are underlined; 18 amino acids deleted in allele DEI284 are overlined; the predicted supernumerary helix 4a (H4a) of allele UU3025 is indicated by a broken line. Only the homologous region of HsXRP2 is shown. (b) HAL/HsArl2. Allele EIC8 has a deletion of 15 bp including a splice donor site (∇).

Aims Iatrogenic pulmonary vein (PV) stenosis after radiofrequency catheter ablation for atrial fibrillation (AF) is a new pathology in cardiology. The effects of PV stenosis on the pulmonary circulation are not yet known.

We provide long-term follow-up data in patients with significant PV stenosis including magnetic resonance imaging (MRI) and Swan Ganz (SG) right heart catheterization. The mean pulmonary vascular resistance in our patient group did not decrease during exercise as normally expected. This may indicate that the pulmonary vascular capacity to dilate during exercise was used, in part, at rest to compensate PV stenosis. The potential long-term effects of exercise induced pulmonary hypertension in this patient population are not yet known. At rest, no patient had pulmonary arterial hypertension.

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